The role of tumor-associated macrophages in the progression, prognosis and treatment of endometrial cancer

Tumor-associated macrophages (TAMs) are the main immune cells in tumor microenvironment (TME) of endometrial cancer (EC). TAMs recruitment and polarization EC is regulated by TME EC, culminating a predominantly M2-like macrophage infiltration. promote lymphatic angiogenesis through cytokine secretion, aid escape synergizing with other cells, contribute to development secretion exosomes so as promoting development. hormone- metabolism-dependent cancer, interactions on estrogen receptor (ER) metabolic factors such metabolism glucose, lipids, amino acids. In addition, we have explored predictive significance some TAM-related indicators for prognosis, show remarkable promise target immunotherapy.